Research projects
The NeoDoppler technology is used in multiple projects, which you are welcome to explore below
Right ventricular output and cerebral Doppler patterns in neonatal transition
The Risk of Acquired Neonatal Significant brain Injury during perinatal Transition in Congenital Heart Disease - TRANSIT CHD
Children with complex congenital heart defects have an increased risk of neurodevelopmental challenges. The aim of this study is to better understand the heart-brain connection in the immediate newborn period i infants with Transposition of the Great Arteries (d-TGA) and Hypoplastic Left Heart Syndrome (HLHS).
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NeoDoppler is used for continuous monitoring of cerebral blood flow during the first days of life, combined with longitudinal brain imaging and echocardiography.
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Increased knowledge about the relationship between cardiac and cerebral physiology may lead to better perinatal management and thereby improve neurodevelopmental outcome
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Neo-PDA
​NeoDoppler is used for continuous monitoring of cerebral blood flow in a group of premature infants undergoing transcatheter closure of patent ductus arteriosus (PDA). The aim is to better understand the relationship between systemic and cerebral hemodynamics and to explore the possibilities of continuous monitoring of cerebral blood flow during interventions in a vulnerable patient group.
Monitoring of cerebral perfusion in children with congenital heart defects
Children with congenital heart disease have an increased risk of developing neurological impairment early in life. The reasons for this are multifactorial and not fully understood. Rapid blood pressure changes during cardiac surgery and intensive care affect cerebral autoregulation and may have a detrimental effect on cerebral perfusion.
This project aims to look more closely at the association between arterial blood pressure and cerebral hemodynamics during anesthetic induction, cardiopulmonary bypass, and the immediate postoperative period in children who have cardiac surgery as infants.
We hope that our findings can help to improve neuroprotective strategies during cardiac surgery and intensive care, in order to reduce the burden of neurological impairment and ultimately increase the quality of life in these patients.
​Advancing assessment of neonatal sepsis
by cerebral circulation monitoring
In neonatal medicine, early identification of sepsis and prompt antibiotic treatment are vital for survival. This project aims to deepen our understanding of cerebral hemodynamics in neonatal sepsis by monitoring changes in cerebral blood flow and heart rate variability.
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Collected data will be used to explore how artificial intelligence can support the early detection of clinical deterioration. By enabling faster and more accurate identification of neonatal sepsis, the project seeks to improve survival rates and reduce long-term complications in affected newborns.
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If successful, integrating NeoDoppler and AI-based tools into routine neonatal care could offer a non-invasive, continuous, and intelligent monitoring solution —transforming care for some of the most vulnerable patients.
Advancing Individualized hemodynamic Management in Neonates - AIM-Neo
Premature and critically ill neonates often face complex and unique hemodynamic challenges. A deeper understanding of hemodynamics during the most vulnerable phases of life is essential for delivering precise, individualized care.
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The AIM-Neo project aims to advance neonatal hemodynamic monitoring by using NeoDoppler to gain insights into cerebral blood flow. Our goal is to explore how NeoDoppler can enhance monitoring and clinical management across several high-risk neonatal populations such as premature neonates with patent ductus arteriosus and newborns with pulmonary hypertension.
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AIM-Neo seeks to pave the way for more tailored and individualized monitoring and treatment in neonatal intensive care.​​